Pharmacological & Toxicological Screening Methods –I Question Paper

Here are a Selective questions of previous years questions papers collected by the different sources. this question papers are very helpful to all M. pharm IST Sem students.

Question -02 marks

• Enlist various types of bioassays.
• List the models for screening antileptics.
• Define Nootropics and name the models for evaluating anti-emetics.
• Compare interoceptive and exteroceptors anti-anxiety models.
• Categorize model for screening analgesics.
• Enlist three preclinical screening models of antidiabetics.
• Euthanasia of experimental animals.
• Methods of immunoassay.
• Carrageenan induced paw edema in Albino Wistar rats.
• Different strains and species of laboratory animals.
• Enlist two in-vitro preclinical screening models of antidepressants.
• Preclinical pharmacological screening models of hepatoprotective drugs.
• Anticancer agents.
• What do you mean by Test item in GLP?
• Which chemical is required for fusion of karyoplast with the enucleated cell?
• What is the role of Isoguvacine or muscimol in [ 3H]-GABA receptor binding assay for screening of GABAergic Compounds?
• Name the behavioral test used for assessing spatial learning.
• Which cell line is used for in-vitro NO release test (aphrodisiac activity)?
• Write down the principle of Konzett-Rossler method.
• Why aconitine used in preclinical screening of anti-arrhythmic agents? Write its mechanism of action.
• Enlist various models used for drug screening of non-insulin-dependent diabetes.
• Differentiate heterogeneous and homogenous immunoassay systems.
• What do you mean by micro-dosing studies?
• Write down about (in short) :-
• Euthanasia of experimental animals.
• Anesthetic agent of laboratory animals.
• CPCSEA
• Nootropics
• Immuno suppressants
• Objectives of Immunoassay.
• Insulin Limitations of animal experimentation
• Enlist three Preclinical pharmacological screening models of following
• Analgesics
• Anti -emetic
• Anti hypertensive

M. Pharm Question Paper (1st SEM)

Modern Pharmaceutical Analytical Techniques Question Paper

Advanced Pharmacology- I 

Question -10 marks

• Explain the in-vitro methods used for screening anti-cancer drugs.
• Discuss CPCSEA guidelines to conduct experiments on animals.
• What do you understand about maintenance and breeding of laboratory animals as well as also discuss about significance of Anesthesia on experimental animals?
• Explain in brief about Immunoassay methods its objective and preparation as well as evaluation for preclinical studies.
• Explain any two in-vitro methods for the preclinical screening of anti-epileptics.
• Discuss possible animal alternative models for preclinical screening of immunomodulators.
• Illustrate the preclinical screening models for evaluation of antidiabetics.
• Enlist different in-vitro and in-vivo preclinical screening models of nootropics. Explain any three in-vivo screening models.
• What is homogenous and heterogeneous immunoassay system? Discuss various methods and optimization of immunoassay.
• Discuss different preclinical pharmacological screening models for antiulcer agents.

Question -07 marks

• Explain the production and application of transgenic animals.
• Describe the methods used for screening anti-Parkinson drugs.
• Describe the CPCSEA guideline to conduct experiments on animals.
• Write about immunoassay for insulin.
• Describe different in-vivo preclinical screening models of anxiety.
• What are the main requirements of GLP (Good Laboratory Practice)?
• Discuss different methods used for the screening of sympathomimetic drugs.
• Explain any two in-vivo methods for the preclinical screening of anti-emetics.
• Write a note on in-vivo methods for the screening of anti-inflammatory agents.
• Illustrate any two methods for the preclinical screening of anti-atherosclerosis agents in detail.
• Name any five in-vivo models used for the screening of hepatoprotective agents. Explain any one in detail.
• Describe immunoassay for digoxin in detail.
• What do you mean by bioassay? Write its principle. Enlist various types of bioassay and their application.
• Write down preclinical screening of the Anti cancer agents using in vivo models.
• Discuss in detail about various routes of drug administration in experimental animals.
• Write down preclinical screening of the Anti diarrheal and laxatives using in vivo models.
• Write a note on commonly used experimental animals and other transgenic animal models.
• Write down in short about Hepatoprotective screening methods.
• Explain in brief about Maintenance and breeding of laboratory animals.
• Write down preclinical screening of the Parkinsonism using in vivo models.
• Explain in brief about effects of Anesthesia on experimental animals.
• What do you understand about preclinical screening of the Alzheimer disorder using in vitro animal models?
• Write down different in-vivo preclinical screening models for antifertility agents.
• Describe different in-vivo preclinical screening models of anti- atherosclerotic agents.
• Write about different methods of drug administration in laboratory animals.
• Discuss any two in-vitro screening methods of epilepsy.
• Discuss the animal models for screening anti-psychotics.