Modern Pharmaceutical Analytical Techniques- Question Paper

MOST IMPORTANT QUESTIONS Modern Pharmaceutical Analytical Techniques (M.pharm IST semester) Here are a Selective questions of previous years questions papers collected by the different sources. this question papers are very helpful to all M. pharm IST Sem students.

Question -02 marks

1. Differentiate between bathochromic and hypsochromic shift.
2. Define chromophore and auxochrome.
3. Give the principle of FTIR.
4. Define Spectroscopy.
5. Define term FAB.
6. Define Beer Lambert equation.
7. What is chromophore? How they are different from auxochromes?
8. Differentiate between stretching and bending.
9. How FT-IR different from dispersive IR.
10. Explain the splitting of signals pattern in 1H NMR.
11. How partition chromatography different from adsorption chromatography?
12. Define electrophoresis with suitable example.
13. What are the different types of paper chromatography?
14. What do you mean by HETP?
15. How shielding effect different from deshielding effect.
16. What are the factors influencing chemical shift?
17. How ESI ionization different from MALDI?
18. Discuss the principle of TLC.
19. Define electrophoresis with example.
20. What is isobestic point?
21. What do you mean by wagging? Mention its significance.
22. What is matrix interference? Give examples.
23. What do you understand by chemical shift reagent?
24. What is APPI in MS technique?
25. Briefly explain micro bore columns of HPLC.
26. Write the stationary phases used in Gel chromatography.
27. What is Nernst equation?
28. What do you know about derivative DTA technique?
29. What is Van-Deemter equation?
30. Define Braggs law.
31. How DTA different from DSC?
32. Differentiate between RIA and ELISA.

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Question -10 marks

1. Describe principle, instrumentation and application of HPLC.
2. Describe Chemical shift and differentiate between 1H NMR and 13C NMR.
3. Discuss the construction and working of FT-IR spectrometer with its advantages over dispersive IR. What is an interferogram?
4. Describe the 2D NMR experiment with a neat sketch. Interpret the NMR spectra of propanol & paracetamol with its signals.
5. Explain the principle, procedure and applications of Radio immunoassay technique.
6. Discuss the principle, thermal transitions and instrumentation of DSC/DTA.
7. Discuss the detail description of principle, theory, instrumentation and application of HPLC.
8. What is the different method thermal analysis? Explain the instrumentation and pharmaceutical application of DSC. Explain why
9. Amines absorb at high wavelength in comparison to alcohol in UV.
10. Reverse phase chromatography is more commonly used in analysis of drugs and pharmaceuticals.
11. Mass is not obtained for sugars using EI source but it can be obtained in FAB.
12. σ-σ* transition has highest energy than π-π* transition.
13. Volatility and thermostability are two important criteria for Gas chromatography

Advanced Pharmacology-I M.PHARM Question paper 

Cellular and Molecular Pharmacology M. PHARM Question Paper

Question -07 marks

1. Discuss the choice of solvents and solvent effect in UV/visible spectroscopy.
2. Calculate the NMR signals for n-butane and isobutane.
3. Write about interferences in AAS and FES. Mention the methods to correct it.
4. Discuss the types of paper chromatography with its applications.
5. Describe the working of tandem mass analyzer with its merits.
6. Write short notes on capillary electrophoresis.
7. Describe the principle & instrumentation of thermo gravimetric analysis.
8. Elaborate the factors for quenching with its counteracting measures to avoid it.
9. Describe the splitting pattern of CH3-CH2-OH, CH3-CHO, CH3(CH2)4 CH3, C6 H6, CH3 C6 H5.
10. Define Mclafferty rearrangement and discuss mass fragmentation rule.
11. How HPTLC chromatography superior from TLC chromatography.
12. Describe principle, instrumentation and application of potentiometry.
13. Give principle, theory and instrumentation of UV/Visible spectroscopy.
14. Discuss the various interferences used in flame spectroscopy.
15. Give the proper NMR signal in following compounds i) Propanol ii) Acetic acid iii) Aspirin iv) Paracetamol.
16. What are immunological assays? And discuss the differences between RIA and ELISA.
17. Discuss the principle, instrumentation and application of potentiometry.
18. Write a short note on 2-D NMR.
19. Discuss the different types of ionization technique in mass spectroscopy.
20. What is electrophoresis? And discuss their types.
21. Differentiate between gel and ion exchange chromatography.
22. Discuss X-ray crystallography and application of X-ray diffraction.
23. Briefly describe Immunological assays and discuss about RIA and ELISA.