Biopharmaceutics and Pharmacokinetics Question paper

MOST IMPORTANT QUESTIONS of Biopharmaceutics and Pharmacokinetics (B.pharm 6th semester), Here are a Selective questions of previous years questions papers collected by the different sources. this question papers are very helpful to all B. pharm 6th Sem students.

Question -02 marks

• Write the name the various barriers for drugs distribution.
• Define apparent volume of distribution and protein binding of drug.
• Define renal clearance. Give the name of non-renal routs of drug excretion of drugs.
• What is the advantage of IV infusion injection.
• Define bio-availability and bio-equivalence.
• Classify different types of pharmacokinetics models.
• Enumerate the factors affecting drug distribution.
• Write the difference between absolute with relative bioavailability.
• Give the advantage of physiological models.
• Define nonlinear pharmacokinetics.
• Define total clearance.
• What is the significance of maintain steady state drug levels in pharmacokinetics?.
• Give Michaelis equation.

Question -10 marks

• Enlist various factors influencing GI absorption of a drug from its dosage form and explain physicochemical factors affecting drug absorption in detail.
• Discuss in detail two-compartment open model for a drug administration as IV bolus. Give the schematic representation, graphs and equation for the same.
• Discuss the various mechanism of drug absorption through GIT.
• How will you calculate loading dose? Discuss its role in maintains of dose.
• Describe Michaelis mention methods of estimation pharmacokinetic parameters.
• What is the difference between linear and non- linear pharmacokinetics? List out the reasons for non-linearity in pharmacokinetics studies.

Question -07 marks

• Discuss in detail the various pharmaceutical factors affecting drug absorption.
• Explain the following terms- Clearance, Total body clearance, Hepatic clearance and renal clearance.
• Explain in detail the plasma level time curve for a two compartment open model.
• What do you mean by drug metabolism? Explain factors affecting renal excretion of drugs.
• Enumerate the objective of bioavailability. Discuss the direct methods for its assessment.
• Give the kinetics of protein binding along with its clinical significance
• What is AUC? Describe the trapezoidal methods for its calculation.
• Describe the method to calculate absorption rate constant for one compartment open model extra vascular first order kinetics.
• What is the reason behind initial rapid decline and terminal slow decline of the conc. of drug in the central compartment? Discuss the reason.
• How will you affect dosage adjustment in renal failure?
• Describe the various methods aimed at enhancing bioavailability of drug from its dosage form.
• Describe the kinetics of capacity limited or suitable processes of non linearity.