Biopharmaceutics and Pharmacokinetics Question paper

MOST IMPORTANT QUESTIONS of Biopharmaceutics and Pharmacokinetics (B.pharm 6th semester), Here are a Selective questions of previous years questions papers collected by the different sources. this question papers are very helpful to all B. pharm 6th Sem students.

Question -02 marks

  • Write the name the various barriers for drugs distribution.
  • Define apparent volume of distribution and protein binding of drug.
  • Define renal clearance. Give the name of non-renal routs of drug excretion of drugs.
  • What is the advantage of IV infusion injection.
  • Define bio-availability and bio-equivalence.
  • Classify different types of pharmacokinetics models.
  • Enumerate the factors affecting drug distribution.
  • Write the difference between absolute with relative bioavailability.
  • Give the advantage of physiological models.
  • Define nonlinear pharmacokinetics.
  • Define total clearance.
  • What is the significance of maintain steady state drug levels in pharmacokinetics?.
  • Give Michaelis equation.

Question -10 marks

  • Enlist various factors influencing GI absorption of a drug from its dosage form and explain physicochemical factors affecting drug absorption in detail.
  • Discuss in detail two-compartment open model for a drug administration as IV bolus. Give the schematic representation, graphs and equation for the same.
  • Discuss the various mechanism of drug absorption through GIT.
  • How will you calculate loading dose? Discuss its role in maintains of dose.
  • Describe Michaelis mention methods of estimation pharmacokinetic parameters.
  • What is the difference between linear and non- linear pharmacokinetics? List out the reasons for non-linearity in pharmacokinetics studies.

Question -07 marks

  • Discuss in detail the various pharmaceutical factors affecting drug absorption.
  • Explain the following terms- Clearance, Total body clearance, Hepatic clearance and renal clearance.
  • Explain in detail the plasma level time curve for a two compartment open model.
  • What do you mean by drug metabolism? Explain factors affecting renal excretion of drugs.
  • Enumerate the objective of bioavailability. Discuss the direct methods for its assessment.
  • Give the kinetics of protein binding along with its clinical significance
  • What is AUC? Describe the trapezoidal methods for its calculation.
  • Describe the method to calculate absorption rate constant for one compartment open model extra vascular first order kinetics.
  • What is the reason behind initial rapid decline and terminal slow decline of the conc. of drug in the central compartment? Discuss the reason.
  • How will you affect dosage adjustment in renal failure?
  • Describe the various methods aimed at enhancing bioavailability of drug from its dosage form.
  • Describe the kinetics of capacity limited or suitable processes of non linearity.

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